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Adam Cribbs
I completed my Ph.D. in molecular T cell immunology at Imperial College London in May 2013 and, after a two-year period of working as a post-doctoral scientist investigating the epigenetics of T cell activation at the University of Oxford; I was successful at applying for a highly competitive 3 year MRC Fellowship in Computational Biology (Computational Genomics and Training Centre (CGAT) program), also at the University of Oxford.
As a result of my extensive computational training at CGAT, I have developed a number of core competencies in statistics, mathematics and software development, enabling the difficult analysis and interpretation of next-generation sequencing data. It was during this time that I developed a strong appreciation of the power of combining different ‘omics’ datasets to facilitate drug discovery. As such, I have been involved in a number of collaborations across a wide range of disease models to identify potentially druggable targets using systems biology tools.
Following the completion of my MRC fellowship I was appointed group leader in systems biology at the Botnar research Centre.
Education/Employment
Group Leader in Systems Biology
University of Oxford
Botnar Research Centre
present - 2018
- Managing a team of 2 computational postdoctoral researchers and supervising two Dphil students
MRC Career Development Fellowship in Computational Biology
University of Oxford
N/A
2018 - 2015
- Development of computational biology skills for next-generation sequencing and big data analysis.
- Collaborative projects with researchers throughout the University of Oxford.
Junior Research Fellowship (JRF)
University of Oxford
Campion hall
2018 - 2016
- Provided financial support to attend conferences and purchase training resources.
- Have developed collaborative links in ethical studies that has resulted in a publication: “Ethical considerations regarding genome editing and its inheritance”.
Postdoctoral Scientist in Immunology & Epigenetics
University of Oxford
Botnar Research Centre
2015 - 2013
- Investigating the epigenetics of NK cells and T cells in rheumatoid arthritis
- Supervised by Professor Sir Marc Feldmann and Professor Udo Oppermann
PhD in Molecular T Cell Immunology
Imperial College London
Kennedy Institute of Rheumatology
2013 - 2009
- Thesis: The molecular mechsnism of defective regulatory T cell function in Rheumatoid Arthritis
- Supported by a highly competitive studentship from the Kennedy Arthritis Trust.
Funding
The Tendon Seed Network (Part of the Human Cell Atlas) - £1,500,000
Co-applicant
ChanZuckerberg Initiative
2022 - 2019
Understanding the epigenetic mechanisms of chemotherapy resistance in medulloblastoma - £ 111,000
Oxford lead
The Royal Society
2022 - 2019
Advanced Oligonucleotide Capture Beads - £369,362
Co-applicant
UK Innovation
2021 - 2020
Therapeutic targeting and understanding of oncogenic driver networks in chordoma
Lead
BCRT
2021 - 2019
Investigating epigenetic heterogeneity using single cell RNA-seq in multiple myeloma - £15,000
Lead
CRUK Oxford Development Fund (AstraZeneca supported)
2020 - 2019
Transcriptional development of human primary osteocytes in a 3D bone organ - £25,382
Co-applicant
Organ-on-a-chip
2020 - 2019
Patents
Biomarkers and their uses thereof in diagnosing pre-eclampsia
N/A
N/A
2018
- Application number GB1806042.6
The diagnosis of rheumatoid arthritis using DNA methylation
N/A
N/A
2014
- Application number GB1400248.9
- Sole inventor
Publications
Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolism
Adam P Cribbs, Stefan Terlecki-Zaniewicz, Martin Philpott, Jeroen Baardman, David Ahern, Morten Lindow, Susanna Obad, Henrik Oerum, Brant Sampey, Palwinder K Mander, Henry Penn, Paul Wordsworth, Paul Bowness, Menno de Winther, Rab K Prinjha, Marc Feldmann and Udo Oppermann. PNAS
N/A
2020
An ontogenetic switch drives the positive and negative selection of B cells
Xijin Xu, Mukta Deobagkar-Lele, Katherine R Bull, Tanya L: Cockford, Adam J Mead, Adam P Cribbs, David Sims, Consuelo Anzilotti and Richard Cornall. PNAS
N/A
2020
Mass cytometry analysis reveals a distinct immune environment in peritoneal fluid in endometriosis: a characterisation study
Guo M, Bafligil C, Tapmeier T, Manek S, Shang C, Martinez F, Schmidt N, Obendorf M, Hess-Stumpp H, Zollner T, Kennedy S, Becker C, Zondervan K, Cribbs AP* and Oppermann U. BMC Medicine. *Senior corresponding author
N/A
2020
A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function
Vincent Fagan, Catrine Johansson, Carina Gileadi, Octovia Monteiro, James E Dunford, Reshma Nibhani, Martin Philpott, Jessica Malzahn, Graham Wells, Ruth Faram, Adam P C ribbs, Nadia Halidi, Fengling Li, Irene Chau, Holger Greschnik, Sirkannathasan Velupillai, Adellah Allali-Hassani, James Bennett, Thomas Christott, Charline Giroud, Andrew Lewis, Kilian V M Huber, Nick Athanasou, Chas Bountra, Manfred Jung, Roland Schule, Masoud Vedadi, Cheryl Arrowsmith, Yan Xiong, Jian Jin, Oleg Fedorov, Gillian Farnie, Paul E Brennan and Udo Oppermann. J Med Chem
N/A
2019
Maternal circulating syncytiotrophoblast-derived extracellular vesicles contain biologically active 5’-tRNA halves
William R Cooke, Adam P Cribbs, Wei Zhang, Neva Kandzija, Carolina Motta-Mejia, Eszter Dombi, Rannya Ria Ana, Sofia Cerdeira, Christopher Redman and Manu Vatish. Biochem Biophys Res Commun
N/A
2019
CGAT-core, a python framework for building scalable, reproducible computational biology workflows.
Adam P. Cribbs, Sebastian Luna-Valero, Charlotte George, Ian M. Sudbery, Antonio J. Berlanga-Taylor, Stephen N. Sansom, Tom Smith, Nicholas E. Ilott, Jethro Johnson, Jakub Scaber, Katherine Brown, David Sims, Andreas Heger. F1000 Research
N/A
2019
Bromodomain inhibition of the coactivators CBP/EP300 facilitates cellular reprogramming.
Ayyub Ebrahimi, Kenan Sevin , Glben Grhan Sevin , Adam Cribbs , Martin Philpott , Frat Uyulur , Tunc Morova , James Dunford , Sencer Gklemez , _ule Ar , Udo Oppermann. Nature Chemical Biology
N/A
2019
Human immunodeficiency reveals the Zn2+-dependence of B cell development
Consuelo Anzilotti , David Swan , Bertrand Boisson , Mukta Deobagkar-Lele , Pauline Chabosseau , Karin Engelhardt , Xijin Xu , Katherine Bull , Eleanor Cawthorne , Adam Cribbs , Ms. Tanya Crockford , Tarana Dang , Amy Fearn , Emma Fenech , Sarah de Jong , Dr. Cindy Ma , David Sims , Yaobo Xu , Andrew Cant, Gary Kleiner , T Leahy , M de la Morena , Jennifer Puck , Ralph Shapiro , Mirjam van der Burg , John Christianson , Benjamin Davies , John McGrath , Stefan Przyborski , Guy Rutter , Mauro Santibanez Koref , Prof. Stuart Tangye , Andreas Werner , Jean-Laurent Casanova , Richard Cornall , Mary Ellen Conley. Nature Immunology
N/A
2019
Design and characterisation of covalent inhibitors of KDM5.
Saleta Vazquez-Rodriguez; Miranda Wright; Catherine M. Rogers; Adam Cribbs; Srikannathasan Velupillai; Martin Philpott; Henry Lee; James E Dunford; Kilian V. M. Huber; Mathew B. Robers; James D. Vasta; Marie Laetitia Thezenas; Sarah Bonham; Benedikt Kessler; James Bennett; Oleg Fedorov; Florence Raynaud; Adam Donovan; Julian Blagg; Vassilios Bavetsias; Udo Oppermann; Akane Kawamura; Paul Brennan. Angewandte Chemie
N/A
2018
Invasive Nontyphoidal salmonella exploits divergent immune evasion strategies in infected and bystander dendritic cells
Anna Aulicino, Kevin Rue-Albrecht, Lorena Preciado-Llanes, Giorgio Napolitani, Neil Ashley, Tim Ambrose, Adam Cribbs, Melita Gordon, David Sims, Alison Simmons. Nature Immunology
N/A
2018
Ethical considerations regarding genome editing and its inheritance
Adam P Cribbs and Sumeth Perera
N/A
2017
Production and concentration of lentivirus for transduction of primary T cells
Alan Kennedy and Adam P Cribbs. Lentiviral vectors and exosomes as gene and protein delivery tools. Spinger
N/A
2016
The role of kynuernine pathway in inflammatory disease.
Adam P cribbs and Richard Williams. Spinger
N/A
2015
Indoleamine 2,3-dioxygenase-1 is protective in atherosclerosis and its metabolites provide new opportunities for drug development
Jennifer E Cole, Nagore Astola, Adam P Cribbs, Micheal E Goddard, Inhye Park, Patricia Green, Alun H Davies, Richard O Williams, Marc Feldmann and Claudia Monaco. PNAS
N/A
2015
Understanding the role of DNA methylation in rheumatoid arthritis - therapeutic and diagnostic implications
Adam P cribbs, Marc Feldmann and Udo Oppermann. Therapeutic advances in musculoskeletal diseases
N/A
2015
Methotrexate restores regulatory T cell function through demethylation of the foxp3 upstream enhancer in patients with rheumatoid arthritis.
Adam P Cribbs, Alan Kennedy, Henry Penn, Parisa Amjadi, Patricia Green, Khaja Syed, Bernard Gregory Fionula M. Brennan and Richard O. Williams. Arthritis & Rheumatism
N/A
2015
Hypomethylation of an upstream enhancer in the Foxp3 locus correlates with elevated gene expression in human regulatory T cells
Alan Kennedy, Emily M. Schmidt, Adam P. Cribbs, Henry Penn, Parisa Amjadi, Khaja Syed, Jordan E. Read, Patricia Green, Bernard Gregory and Fionula M. Brennan. European Journal of Immunology
N/A
2014
Defective regulatory T cells in rheumatoid arthritis fail to activate IDO due to methylation of an NFAT binding site within the CTLA-4 promoter
Adam P Cribbs, Alan Kennedy, Jordan E. Read, Parisa Amjadi, Patricia Green, Henry Penn, Khaja Syed, Szymon W. Manka, Bernard Gregory Fionula M. Brennan and Richard O. Williams. Arthritids & Rheumatology. Research highlight in Nature Reviews Rheumatology
N/A
2014
Resistance to regulatory T cell-mediated suppression in rheumatoid arthritis can be bypassed by ectopic foxp3 expression in pathogenic synovial cells.
Paul A Beavis, Bernard Gregory, Patricia Green, Adam P Cribbs, Alan Kennedy, Parisa Amjadi, Andrew C Palfreeman, Marc Feldmann and Fionula Brennan. PNAS
N/A
2011