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Last updated on 2020-03-17.

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Adam Cribbs

I completed my Ph.D. in molecular T cell immunology at Imperial College London in May 2013 and, after a two-year period of working as a post-doctoral scientist investigating the epigenetics of T cell activation at the University of Oxford; I was successful at applying for a highly competitive 3 year MRC Fellowship in Computational Biology (Computational Genomics and Training Centre (CGAT) program), also at the University of Oxford.

As a result of my extensive computational training at CGAT, I have developed a number of core competencies in statistics, mathematics and software development, enabling the difficult analysis and interpretation of next-generation sequencing data. It was during this time that I developed a strong appreciation of the power of combining different ‘omics’ datasets to facilitate drug discovery. As such, I have been involved in a number of collaborations across a wide range of disease models to identify potentially druggable targets using systems biology tools.

Following the completion of my MRC fellowship I was appointed group leader in systems biology at the Botnar research Centre.

Education/Employment

Group Leader in Systems Biology

University of Oxford

Botnar Research Centre

present - 2018

  • Managing a team of 2 computational postdoctoral researchers and supervising two Dphil students

MRC Career Development Fellowship in Computational Biology

University of Oxford

N/A

2018 - 2015

  • Development of computational biology skills for next-generation sequencing and big data analysis.
  • Collaborative projects with researchers throughout the University of Oxford.

Junior Research Fellowship (JRF)

University of Oxford

Campion hall

2018 - 2016

  • Provided financial support to attend conferences and purchase training resources.
  • Have developed collaborative links in ethical studies that has resulted in a publication: “Ethical considerations regarding genome editing and its inheritance”.

Postdoctoral Scientist in Immunology & Epigenetics

University of Oxford

Botnar Research Centre

2015 - 2013

  • Investigating the epigenetics of NK cells and T cells in rheumatoid arthritis
  • Supervised by Professor Sir Marc Feldmann and Professor Udo Oppermann

PhD in Molecular T Cell Immunology

Imperial College London

Kennedy Institute of Rheumatology

2013 - 2009

  • Thesis: The molecular mechsnism of defective regulatory T cell function in Rheumatoid Arthritis
  • Supported by a highly competitive studentship from the Kennedy Arthritis Trust.

Funding

The Tendon Seed Network (Part of the Human Cell Atlas) - £1,500,000

Co-applicant

ChanZuckerberg Initiative

2022 - 2019

Understanding the epigenetic mechanisms of chemotherapy resistance in medulloblastoma - £ 111,000

Oxford lead

The Royal Society

2022 - 2019

Advanced Oligonucleotide Capture Beads - £369,362

Co-applicant

UK Innovation

2021 - 2020

Therapeutic targeting and understanding of oncogenic driver networks in chordoma

Lead

BCRT

2021 - 2019

Investigating epigenetic heterogeneity using single cell RNA-seq in multiple myeloma - £15,000

Lead

CRUK Oxford Development Fund (AstraZeneca supported)

2020 - 2019

Transcriptional development of human primary osteocytes in a 3D bone organ - £25,382

Co-applicant

Organ-on-a-chip

2020 - 2019

Patents

Biomarkers and their uses thereof in diagnosing pre-eclampsia

N/A

N/A

2018

  • Application number GB1806042.6

The diagnosis of rheumatoid arthritis using DNA methylation

N/A

N/A

2014

  • Application number GB1400248.9
  • Sole inventor

Publications

Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolism

Adam P Cribbs, Stefan Terlecki-Zaniewicz, Martin Philpott, Jeroen Baardman, David Ahern, Morten Lindow, Susanna Obad, Henrik Oerum, Brant Sampey, Palwinder K Mander, Henry Penn, Paul Wordsworth, Paul Bowness, Menno de Winther, Rab K Prinjha, Marc Feldmann and Udo Oppermann. PNAS

N/A

2020

An ontogenetic switch drives the positive and negative selection of B cells

Xijin Xu, Mukta Deobagkar-Lele, Katherine R Bull, Tanya L: Cockford, Adam J Mead, Adam P Cribbs, David Sims, Consuelo Anzilotti and Richard Cornall. PNAS

N/A

2020

Mass cytometry analysis reveals a distinct immune environment in peritoneal fluid in endometriosis: a characterisation study

Guo M, Bafligil C, Tapmeier T, Manek S, Shang C, Martinez F, Schmidt N, Obendorf M, Hess-Stumpp H, Zollner T, Kennedy S, Becker C, Zondervan K, Cribbs AP* and Oppermann U. BMC Medicine. *Senior corresponding author

N/A

2020

A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function

Vincent Fagan, Catrine Johansson, Carina Gileadi, Octovia Monteiro, James E Dunford, Reshma Nibhani, Martin Philpott, Jessica Malzahn, Graham Wells, Ruth Faram, Adam P C ribbs, Nadia Halidi, Fengling Li, Irene Chau, Holger Greschnik, Sirkannathasan Velupillai, Adellah Allali-Hassani, James Bennett, Thomas Christott, Charline Giroud, Andrew Lewis, Kilian V M Huber, Nick Athanasou, Chas Bountra, Manfred Jung, Roland Schule, Masoud Vedadi, Cheryl Arrowsmith, Yan Xiong, Jian Jin, Oleg Fedorov, Gillian Farnie, Paul E Brennan and Udo Oppermann. J Med Chem

N/A

2019

Maternal circulating syncytiotrophoblast-derived extracellular vesicles contain biologically active 5’-tRNA halves

William R Cooke, Adam P Cribbs, Wei Zhang, Neva Kandzija, Carolina Motta-Mejia, Eszter Dombi, Rannya Ria Ana, Sofia Cerdeira, Christopher Redman and Manu Vatish. Biochem Biophys Res Commun

N/A

2019

CGAT-core, a python framework for building scalable, reproducible computational biology workflows.

Adam P. Cribbs, Sebastian Luna-Valero, Charlotte George, Ian M. Sudbery, Antonio J. Berlanga-Taylor, Stephen N. Sansom, Tom Smith, Nicholas E. Ilott, Jethro Johnson, Jakub Scaber, Katherine Brown, David Sims, Andreas Heger. F1000 Research

N/A

2019

Bromodomain inhibition of the coactivators CBP/EP300 facilitates cellular reprogramming.

Ayyub Ebrahimi, Kenan Sevin , Glben Grhan Sevin , Adam Cribbs , Martin Philpott , Frat Uyulur , Tunc Morova , James Dunford , Sencer Gklemez , _ule Ar , Udo Oppermann. Nature Chemical Biology

N/A

2019

Human immunodeficiency reveals the Zn2+-dependence of B cell development

Consuelo Anzilotti , David Swan , Bertrand Boisson , Mukta Deobagkar-Lele , Pauline Chabosseau , Karin Engelhardt , Xijin Xu , Katherine Bull , Eleanor Cawthorne , Adam Cribbs , Ms. Tanya Crockford , Tarana Dang , Amy Fearn , Emma Fenech , Sarah de Jong , Dr. Cindy Ma , David Sims , Yaobo Xu , Andrew Cant, Gary Kleiner , T Leahy , M de la Morena , Jennifer Puck , Ralph Shapiro , Mirjam van der Burg , John Christianson , Benjamin Davies , John McGrath , Stefan Przyborski , Guy Rutter , Mauro Santibanez Koref , Prof. Stuart Tangye , Andreas Werner , Jean-Laurent Casanova , Richard Cornall , Mary Ellen Conley. Nature Immunology

N/A

2019

Design and characterisation of covalent inhibitors of KDM5.

Saleta Vazquez-Rodriguez; Miranda Wright; Catherine M. Rogers; Adam Cribbs; Srikannathasan Velupillai; Martin Philpott; Henry Lee; James E Dunford; Kilian V. M. Huber; Mathew B. Robers; James D. Vasta; Marie Laetitia Thezenas; Sarah Bonham; Benedikt Kessler; James Bennett; Oleg Fedorov; Florence Raynaud; Adam Donovan; Julian Blagg; Vassilios Bavetsias; Udo Oppermann; Akane Kawamura; Paul Brennan. Angewandte Chemie

N/A

2018

Invasive Nontyphoidal salmonella exploits divergent immune evasion strategies in infected and bystander dendritic cells

Anna Aulicino, Kevin Rue-Albrecht, Lorena Preciado-Llanes, Giorgio Napolitani, Neil Ashley, Tim Ambrose, Adam Cribbs, Melita Gordon, David Sims, Alison Simmons. Nature Immunology

N/A

2018

Ethical considerations regarding genome editing and its inheritance

Adam P Cribbs and Sumeth Perera

N/A

2017

Production and concentration of lentivirus for transduction of primary T cells

Alan Kennedy and Adam P Cribbs. Lentiviral vectors and exosomes as gene and protein delivery tools. Spinger

N/A

2016

The role of kynuernine pathway in inflammatory disease.

Adam P cribbs and Richard Williams. Spinger

N/A

2015

Indoleamine 2,3-dioxygenase-1 is protective in atherosclerosis and its metabolites provide new opportunities for drug development

Jennifer E Cole, Nagore Astola, Adam P Cribbs, Micheal E Goddard, Inhye Park, Patricia Green, Alun H Davies, Richard O Williams, Marc Feldmann and Claudia Monaco. PNAS

N/A

2015

Understanding the role of DNA methylation in rheumatoid arthritis - therapeutic and diagnostic implications

Adam P cribbs, Marc Feldmann and Udo Oppermann. Therapeutic advances in musculoskeletal diseases

N/A

2015

Methotrexate restores regulatory T cell function through demethylation of the foxp3 upstream enhancer in patients with rheumatoid arthritis.

Adam P Cribbs, Alan Kennedy, Henry Penn, Parisa Amjadi, Patricia Green, Khaja Syed, Bernard Gregory Fionula M. Brennan and Richard O. Williams. Arthritis & Rheumatism

N/A

2015

Hypomethylation of an upstream enhancer in the Foxp3 locus correlates with elevated gene expression in human regulatory T cells

Alan Kennedy, Emily M. Schmidt, Adam P. Cribbs, Henry Penn, Parisa Amjadi, Khaja Syed, Jordan E. Read, Patricia Green, Bernard Gregory and Fionula M. Brennan. European Journal of Immunology

N/A

2014

Defective regulatory T cells in rheumatoid arthritis fail to activate IDO due to methylation of an NFAT binding site within the CTLA-4 promoter

Adam P Cribbs, Alan Kennedy, Jordan E. Read, Parisa Amjadi, Patricia Green, Henry Penn, Khaja Syed, Szymon W. Manka, Bernard Gregory Fionula M. Brennan and Richard O. Williams. Arthritids & Rheumatology. Research highlight in Nature Reviews Rheumatology

N/A

2014

Simplified production and concentration of lentiviral vectors to achieve high transduction in primary human T cells.

Adam P Cribbs, Alan Kennedy, Bernard Gregory and Fionula M Brennan. BMC Biotechnology

N/A

2013

Resistance to regulatory T cell-mediated suppression in rheumatoid arthritis can be bypassed by ectopic foxp3 expression in pathogenic synovial cells.

Paul A Beavis, Bernard Gregory, Patricia Green, Adam P Cribbs, Alan Kennedy, Parisa Amjadi, Andrew C Palfreeman, Marc Feldmann and Fionula Brennan. PNAS

N/A

2011